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KMID : 0928320070070040261
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Korean Journal of Health Promotion and Disease Prevention
2007 Volume.7 No. 4 p.261 ~ p.266
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Effects of Alkoxyglycerol Intake on Lymphocyte Subpopulation in Human
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Kim Nam-Sik
Kim Heon
Eom Sang-Yong
Zhang Yan-Wei
Kim Yong-Dae
Song Hyung-Geun
Kim Sung-Hoon
Lee Sang-Won
Lee Chung-Jong
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Abstract
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Background : It is known that alkoxglycerol can affect to immune function in human. A randomized, double blind, placebo-controlled human intervention study involving 69 healthy volunteers (23 men and 46 women) was performed to investigate the effect of alkoxyglycerol on lymphocyte subpopulations in human.
Methods : Volunteers were recruited and randomly distributed into two groups, one receiving an alkoxyglycerol (13.5 g/day) and the other a placebo orally for 10 weeks. Lymphocyte subpopulations (T cell, helper T cell, suppressor T cell, and B cell) were evaluated before and after 10-week alkoxyglycerol intake.
Results: Leukocytes and lymphocytes number were not significantly changed by 10-week alkoxyglycerol intake. However, the percentages of T cell, helper T cell and B cell were significantly increased by 10-week alkoxyglycerol intake.
Conclusions: These results suggest that administration of alkoxyglycerol may affect the immune function by changing the percentage of lymphocyte subpopulations in humans.
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KEYWORD
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Alkoxyglycerol, human intervention study, lymphocyte subpopulation, T cell, B cell
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